Beilstein J. Org. Chem.2014,10, 2827–2835, doi:10.3762/bjoc.10.300
of other dietary fibers. To identify this mechanism, we investigated the interaction of α-CD with lecithin and bile salts, which are essential components for the dissolution of cholesterol in the small intestine, and the effect of α-CD on micellarsolubility of cholesterol.
Results: α-CD was added to
Fed-State Simulated Intestinal Fluid (FeSSIF), and precipitation of a white solid was observed. Analytical data showed that the precipitate was a lecithin and α-CD complex with a molar ratio of 1:4 or 1:5. The micellarsolubility of cholesterol in the mixture of FeSSIF and α-CD was investigated, and
dietary fibers. The decrease in micellar cholesterol solubility in the FeSSIF was the strongest with α-CD addition.
Keywords: α-cyclodextrin; bile salt micelles; cholesterol; lecithin; micellarsolubility; Introduction
α-Cyclodextrin (α-CD) is a ring molecule composed of six glucose units that has an
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Graphical Abstract
Figure 1:
Image of the FeSSIF and other buffers with and without α-CD. α-CD was added into the FeSSIF or othe...